Beginning Wednesday, August 5, MTA New York City Transit will provide new overnight bus service for customers between Manhattan and Brooklyn, and between Manhattan and the Bronx.
The new M99 will operate run every 20 minutes from approximately 1AM and 6AM, between East New York in Brooklyn and the West 42nd Street pier in Manhattan. The new Bx99 will run every 20 minutes from approximately 1AM and 6AM, between Woodlawn in the Bronx and the West Village serving the east and west sides of Manhattan, crossing Midtown along 57th Street. 
Please visit mta.info/overnight for more information and use the MyMTA app or call 511 to plan your trip.